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Squaring off at 9 p.m. EDT in Danville, Kentucky are Vice-President Joe Biden and vice-presidential candidate Paul Ryan, in their first and only debate.
After the shellacking Mitt Romney gave President Obama in the first presidential debate many political experts are expecting Biden to come out on the offensive in an attempt to regain some of the president's lost ground.
Paul Ryan, in his first national debate, knows that Biden is looking to attack where the president did not. As the Chair of the House Budget Committee, Ryan should be ready to defend his running mate and continue the attack on the president. Expect Ryan to focus on the economy, specifically federal debt, unemployment and job creation.
"I'd be surprised if there weren't far more fireworks in this debate than there were in the first presidential debate," University of Maine political science professor Mark Brewer told Reuters.
While the debate will focus on domestic and foreign policies, here are other things you should watch for.